|Even in Vitamin D Deficiency 1, 25 Dihydroxyvitamin D3 Level Is Normal in Pregnant Women|
|Levent Ozsari1, Pinar Kumru2, Osman Ipcioglu3, Ayşen Ozkoral4, Ismet Gun5, Eylem Cagiltay1, Arif Yonem1, Yasam Kemal Akpak6|
|1Departments of Endocrinology and Metabolism, Medical Sciences University, Sultan Abdulhamid Han Hospital, Istanbul, Turkey
2Departments of Obstetrics and Gynecology, Zeynep Kamil Maternal and Child Diseases Edu-cational and Research Hospital, Istanbul, Turkey
3Department of Biochemistry, Medical Sciences University, Sultan Abdulhamid Han Hospital, Istanbul, Turkey
4Department of Biochemistry, Zeynep Kamil Maternal and Child Diseases Educational and Research Hospital, Istanbul, Turkey
5Departments of Obstetrics and Gynecology, Medical Sciences University, Sultan Abdulhamid Han Hospital, Istanbul, Turkey
6Departments of Obstetrics and Gynecology, Diskapi Yildirim Beyazid Training Hospital Ankara, Turkey
IJWHR 2019; 7: 024-028
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Keywords : Pregnancy, Vitamin D deficiency, The 1,25 dihydroxyvitamin D3 status
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Objectives: Vitamin D deficiency is a controversial issue in pregnant women. The 1,25 dihydroxyvitamin D3 level is higher in pregnant than non-pregnant women. This study aimed to investigate the 1,25 di-hydroxyvitamin D3 status in vitamin D deficient pregnant women at the first trimester.
Materials and Methods: This study was conducted during December 2011 and April 2012 in 2 hospitals of Istanbul, Turkey. Pregnant women who attended for the regular examination on the 12th gestational week were randomly assigned. They were divided into 2 groups including vitamin D deficient (vitamin D <30 ng/mL) and vitamin D optimal (vitamin D ≥30 ng/mL). Serum 25 hydroxyvitamin D3, 1,25 dihydroxyvitamin D3, fibroblast growth factor 23, calcium, phosphate, urinary calcium, and urinary phosphorus levels were measured.
Results: After exclusion of fourteen pregnant women due to inconvenient serum samples, the mean serum 25 hydroxyvitamin D3 level of one hundred sixty outpatient pregnant women was 10.8 ± 16.2 ng/mL. Totally, 132 (85.0%) of these women were vitamin D deficient (25 hy-droxyvitamin D3 level less than 30 ng/mL). Serum 1,25 dihydroxyvitamin D3 and urinary calcium levels were higher in vitamin D deficient than vitamin D optimal group.
Conclusions: Even under severe vitamin D deficiency, the 1,25 dihydroxyvitamin D3 level was high in pregnant women. Active vitamin D status was not compatible with the 25 hydroxyvitamin D3 level in vitamin D deficient pregnant women at the first trimester.
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