|EVEN INVITAMIN D DEFICIENCY 1,25 DIHYDROXYVITAMIN D3 LEVEL IS NORMAL IN PREGNANT WOMEN|
|Levent Ozsari1, Pinar Kumru2, Osman Ipcioglu3, Ayşen Ozkoral4, İsmet Gun5, Eylem Cagiltay1, Arif Yonem1, Yasam Kemal Akpak6|
|1Departments of Endocrinology and Metabolism, Medical Science University Sultan Abdulhamid Han Hospital, Istanbul,TURKEY.
2Departments of Obstetrics and Gynecology, ZeynepKamil Maternal and Child Diseases Educational and Research Hospital, Istanbul,Turkey.
3Department of Biochemistry, Medical Science University Sultan Abdulhamid Han Hospital, Istanbul,TURKEY
4Department of Biochemistry, ZeynepKamil Maternal and Child Diseases Educational and Research Hospital, Istanbul,Turkey.
5Departments of Obstetrics and Gynecology, Medical Science University Sultan Abdulhamid Han Hospital, Istanbul,TURKEY.
6Departments of Obstetrics and Gynecology, Diskapi Yildirim Beyazid Training Hospital Ankara ,TURKEY
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Keywords : Pregnancy, vitamin D deficiency, 1,25 dihydroxyvitamin D3 status
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Objective:Vitamin D deficiency in pregnant women is a controversial issue. During pregnancy 1,25 dihydroxyvitaminD3 level is higher than non-pregnant women. We aimed to investigate1,25 dihydroxyvitaminD3 status in vitamin D deficient pregnant women at the first trimester.
Materials and methods: This study was conducted between December 2011 and April 2012 in two hospitals located in the center of Istanbul/Turkey. Pregnant women who attended for the regular examination on the 12th gestational week were randomly assigned. They were divided into two groups; vitamin D deficient (vitamin D < 30 ng/mL) and vitamin D optimal (vitamin D ≥ 30 ng/mL).One hundred seventy four pregnant women gave written informed consent. Serum 25 hydroxyvitamin D3, 1,25 dihydroxyvitamin D3, fibroblast growth factor 23, calcium, phosphate, urinary calcium, urinary phosphorus levels were measured.
Results: After exclusion of fourteen pregnant women due to inconvenient serum samples, the mean serum 25 hydroxyvitamin D3 level of one hundred sixty outpatient pregnant women was 10,8 ± 16,2 ng/mL. 132 (85,0%) of these women were vitamin D deficient (25 hydroxyvitamin D3 level less than 30 ng/mL). Serum 1,25 dihydroxyvitamin D3, and urinary calcium levels were higher in vitamin D deficient than vitamin D optimal group.
Conclusions: Even severe vitamin D deficiency, 1,25 dihydroxyvitamin D3 level ishigh in pregnant women. Active vitamin D status is not compatible with the 25 hydroxyvitamin D3 level in vitamin D deficientpregnant women at the first trimester.
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