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Jul 2018, Vol 6, Issue 3
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Original Article
Predictive Factors of Antidepressant Response and Remission to Bupropion Extended-Release or Psychosexual Therapy Among Infertile Women With Sexual Dysfunction
Hajar Pasha1, Zahra Basirat1, Mahbobeh Faramarzi2, Farzan Kheirkhah3, Soraya Khafri4
1Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran
3Department of Psychiatry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
4Department of Public Health, Babol University of Medical Sciences, Babol, Iran

IJWHR 2018; 6: 313-320
DOI: 10.15296/ijwhr.2018.52
Viewed : 1005 times
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Keywords : Antidepressant, Psychotherapy, Bupropion, Response, Remission, Infertility, Predictor
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Abstract
Objectives: This study aimed to evaluate the predictive factors of antidepressant response and remission to bupropion extended-release (BUP ER) or psychosexual therapy (PST) among infertile women with sexual dysfunction (SD).

Materials and Methods: As a randomized controlled clinical trial, this prospective study was carried out on 3 groups of BUP ER (n = 31), PST (n = 31), and control (n = 31) in infertile women with SD in Babol, Iran during 2014-2015. Logistic regression was used to detect predictors of antidepressant response and remission.

Results: Antidepressant response and remission rates were 58.1% and 54.8 % respectively in the PST group. Of the infertile women in the BUP group, 41.9% reached response and remission by the end of the study. The results for PST contained 2 predictors: occupation in response and remission (odds ratio [OR] = 0.171, P = 0.036; OR = 0.1, P = 0.013; respectively), and frequency of sexual intercourse in response (OR = 0.124; P = 0.040). The results for BUP contained three predictors: baseline severe depression level in remission (OR = 0.044, P = 0.010), economic status in response and remission (OR = 5.850, P = 0.027), and age difference of spouses in response (P = 0.031).

Conclusions: Depression screening and physician notification of demographic, reproductive and clinical predictors of antidepressant response and remission are necessary for selecting effective treatment interventions.

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