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Jul 2018, Vol 6, Issue 3
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Original Article
Predictive Factors of Antidepressant Response and Remission to Bupropion Extended-Release or Psychosexual Therapy among Infertile Women with Sexual Dysfunction .
Hajar Pasha1, Zahra Basirat1, Mahbobeh Faramarzi2, Farzan Kheirkhah3, Soraya Khafri4
1Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2Social Determinants of Health Research Center, Babol University of Medical Sciences,Babol, Iran
3Departments of Psychiatry, Faculty of Medicine, Babol University of Medical Sciences,Babol, Iran
4Departments of Public Health, Babol University of Medical Sciences, Babol, Iran.

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Keywords : Antidepressant, Psychotherapy, Bupropion, Response, Remission, Infertility, Predictor
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Objectives: This study aimed at evaluating the predictive factors of antidepressant response and remission to bupropion extended-release (BUP ER) or psychosexual therapy (PST) among infertile women with sexual dysfunctions (SD).

Material and Methods: An analysis of prospective data was carried out by originated data from a randomized controlled clinical trial of BUP ER (n=31), PST (n=31), and control (n=31) in infertile women with SD in Babol, Iran (2014-2015). Logistic regression was used to detect predictors of antidepressant response and remission.

Results: Antidepressant response and remission rates were 58.1% and 54.8 % respectively in the PST group. Of the infertile women in BUP group, 41.9% reached response and remission by the end of the study. The results for PST contained two predictors: occupation in response and remission (OR=0.171, P=0.036; OR=0.1, P=0.013; respectively), and frequency of sexual intercourse in response (OR=0.124; P=0.040). The results for BUP contained three predictors: baseline severe depression level in remission (OR= 0.044, P=0.010), economic status in response and remission (OR=5.850, P=0.027) and age difference of spouses in response (P=0.031).

Conclusion: Depression screening and physician notification of demographic, reproduction and clinical predictors of antidepressant response and remission are necessary for selecting effective treatment interventions.

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