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Jul 2017, Vol 5, Issue 3
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The Risk Factors of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis Study
Faezeh Kiani1, Marzieh SaeiGhareNaz2, Fatemeh Sayehmiri3, Kourosh sayehmiri4, Hakimeh Zali5
1Research Center for Prevention of psychosocial impairment, Ilam University of Medical Sciences, Ilam, Iran
2Student Research office , School Of Nursing and Midwifery ShahidBeheshti University Of Medical Sciences , Tehran, Iran
3Proteomics Research Center, ShahidBeheshti University of Medical, Tehran, Iran
4Department of Social Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
5Proteomics Research Center, School of Advanced Technologies in Medicine, ShahidBeheshti University of Medical, Tehran, Iran


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Keywords : Gestational diabetes, Risk factors, Meta-analysis, Iran
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Abstract
Objectives: Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. If it is not controlled, it can cause lots of complications for both mother and fetus. The aim of this study was to investigate the risk factors for GDM in Iran using a meta-analysis study.

Materials and Methods: Different databases including all national scientific databases (Iranmedex, SID, Magiran, Irandoc, and Medlib) and international databases (PubMed/Medline, Scopus, and ISI Web of Knowledge) were searched for published data onrisk factors of GDM in Iran. A total of 21 relevant articles from the period between 2001 and 2015 were finally analyzed. Data synthesis was performed based on the random effects model. Data were analyzed using R software and STATA.

Results: A total of 1658 pregnant women with an average age of 29.15 years were investigated. The mean BMI for the subjects was 27.53. The most common risk factors for GDM were included as follows: high age 64% (95% CI: 53–76), excess weight and obesity 47% (95% CI: 40–54), family history of diabetes 31% (95% CI: 26–36), history of abortion 22% (95% CI:16–27), history of glycosuria 12% (95% CI: 4–19), history of macrosomia 10% (95% CI: 6 –13), delivery ≥ 5 case 10% (95% CI: 2–17), history of gestational hypertension 5% (95% CI: 1–8), history of preeclampsia 4% (95% CI:2 –7), history of diabetes in pregnancy 4% (95% CI:1–8), history of stillbirths 3% (95% CI: 2–5), delivery < 37 weeks 3% (95% CI: 0–6), previous congenital malformations 1% (95% CI: 0–2) and previous neonatal death 1% (95% CI: 0-2).

Conclusion: Considering that Approximately 40% of cases of diabetes in pregnancy will turn into diabetes over the coming years, control of risk factors can reduce the incidence of diabetes in pregnancy.

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