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Jul 2017, Vol 5, Issue 3
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Original Article
The Effects of Adding vitamin C Vaginal Tablet to Oral Metronidazole on Treatment and Recurrence of Bacterial Vaginosis: A Randomized Triple-blind Clinical Trial
Toktam Dokhanchi, Sakineh Mohammad Alizadeh, Sevil Hakimi, Yusef Javadzadeh, Lida Takallu, Mostafa Gharabaghi Parvin
Women’s Reproductive Health Research Center ,Tabriz university of medical sciences, Tabriz, Iran


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Keywords : Vitamin C, Bacterial vaginosis, Amsel criteria, Nugent criteria
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Abstract
Objective: Bacterial vaginosis (BV) is the most common vaginitis that associated with reduction in vaginal lactobacilli and increased growth of other anaerobic species of bacteria. Vitamin C can be effective in treatment of bacterial vaginosis through production of lactic acid. This study aimed to determine the efficacy of adding vitamin C vaginal to metronidazole on treatment of bacterial vaginosis.

Materials and Methods: This study was a triple- blind randomized clinical trial and was done from July 2015 till November 2015 on 160 women with pure BV who attended gynecologic clinic in Mashhad. They were randomized into intervention and control groups. Intervention group received 500 mg oral metronidazole tablets twice a day along with 250 mg vitamin C vaginal tablets for 7 days and control group received the same dose of oral metronidazole along with placebo for 7 days. Amsel and Nugent criteria were analyzed before, 10 ± 3 and 30 ± 3 days after treatment.

Results: The cure rate based on Amsel and Nugent criteria were 85.9% in intervention group and 52.3% in control group on 10 ± 3 days [Odd Ratio (OR) 5.3, 95% confidence Interval (CI) 2.4 to 11.6] and 87.7% in intervention group and 41.9% in control group on 30 ± 3 days [ OR 9. 8, 95% CI 4.2 to 22.4].

Conclusions: According to the results, it seems that two-drug treatment of BV by oral metronidazole and vitamin C vaginal tablets is more effective than one-drug treatment of BV by oral metronidazole in recovery and non-recurrence.

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