|Comparison of Serum and Uterine Flushing Concentrations of Glycodelin on Days 21-23 of Reproductive Cycle among Women with In Vitro Fertilization Failure versus Normal Fertile Women: A Pilot Study|
|Robabeh Taheripanah1, Marzieh Zamaniyan2, Shahrzad Akhoondzadeh1, Anahita Taheripanah3|
|1Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Obstetrics and Gynecology, Infertility Center,Mazandaran University of Medical Sciences, Tehran, Iran
3Department of Molecular and Cellular Sciences,Faculty of Advanced Sciences and Technology Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
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Keywords : Endometrium, Embryo Implantation, Fertilization in Vitro, Glycodelin Protein, Infertility
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Objectives: Glycodelin is a factor which regulates immunological activity, and is required in implantation window. The present study was conducted to compare glycodelin concentrations in blood and uterine flushing samples from women with IVF failure and fertile controls.
Materials and Methods: This wasa prospective pilot clinical trial including20 women with IVF failure and 19 fertile participants.Both groups initially filled a special questionnaire including their demographic profile and prior failed IVF attempts, then samples of uterine flushing and blood samples were taken to measure glycodelin concentrations.
Results: There were significant differences between mean glycodelin concentrations in the case and control groups, both in serum glycodelin (30.1 ± 5.30 vs.44.5 ± 11.85, P<0.001), and uterine flushing glycodelin concentrations (310.0 ± 67.51 vs. 498.3 ± 119.01, P<0.001). The mean total glycodelin concentration in uterine flushing was higher than serum in both groups(399.4 ± 133.95 vs. 36.9 ±11.52, P< 0.001).
Conclusion: We found a significant decrease in glycodelin concentrations among patients with IVF failure. Since glycodelin has a role in immune system during endometrial receptivity, therefore, it may be required for prevention of IVF failures.
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