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Jul 2017, Vol 5, Issue 3
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Original Article
Comparison of The Complications of Platinum-based Adjuvant Chemotherapy with and without Ginger in a Pilot Study on Ovarian Cancer Patients
Farnaz Shokri, Parvin Mostafa Gharebaghi, Ali Esfahani , Manizheh Sayyah-Melli, Mehri Jafari Shobeiri, Elaheh Ouladsahebmadarek, Morteza Ghojazadeh
Women's Reproductive Health Research Center, Tabriz university of Medical sciences, Tabriz, Iran


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Keywords : Ovarian Cancer, Ginger, Chemotherapy, Outcome
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Abstract
Objective: The principle treatment of ovarian cancer is surgery with or without chemotherapy. The chemotherapy, however, might be ineffective and long with serious side-effects. To obviate these shortcomings, more efficient and safer medications are required, among which ginger has recently gained popularity because of its anti-cancer properties. This study aims to compare outcomes and side-effects of adjuvant chemotherapy with and without ginger in ovarian cancer patients.

Materials and methods Methods: A total of 49patients (20cases and 29controls) with stage I-III, histopathologically proved ovarian cancer underwent cytoreductive surgery followed by platinum-based adjuvant chemotherapy with and without oral investigator-prepared ginger capsules (2gr per day for 6cycles). Potential side-effects, poor 12-month outcome (serum CA125-levels>35U, or radiologic metastasis/recurrence, or death), and 12-month disease-free survival were documented and compared between the two groups.

Results: Poor outcome including serum CA125>35 ,metastasis ,recurrence or death was documented more common in control group (69% versus 40%). metastasis frequency confirmed on CT scan six month after treatment was significantly lower in case group (p=0.04).
There was no significant difference regarding mortality and disease free survival during one year follow up after treatment between two groups (p=0.55). Chemotherapy complications such as nausea, womiting, weight loss ,peripheral neuropathy were detected in case group less than control group but the difference was not significant

Conclusion: Administration of oral ginger is along with a significantly better 12-month outcome in patients on chemotherapy because of ovarian cancer, and accordingly, considering its safety, its administration is recommended.

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