|Calcium With and Without Magnesium for Primary Dysmenorrhea: A Double-Blind Randomized Placebo-Controlled Trial|
|Sakineh Mohammad-Alizadeh Charandabi1, Mojgan Mirghafourvand1, Salimeh Nezamivand-Chegini2, Yousef Javadzadeh3|
|1Department of Midwifery, Faculty of Nursing & Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
2Students’ research committee, Department of Midwifery, Faculty of Nursing & Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
1Pharmaceutics Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Calcium, Magnesium, Primary dysmenorrhea, Rest length, Number of analgesics taken, Pain intensity
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Objectives: To assess effect of co-administration of calcium and magnesium and calcium alone on pain intensity in primary dysmenorrhea.
Materials and Methods: In this study, 63 students with primary dysmenorrhea were randomly allocated into two intervention (receiving one tablet a day combined 600 mg calcium carbonate and 300 mg magnesium stearate, or only 600 mg calcium carbonate from 15th cycle day until no pain day on the following cycle) and one placebo groups. The subjects filled in a diary including pain intensity (0-10 visual analog scale) and rest length for two cycles before and two cycles under intervention. Univariate general linear model was used for data analysis.
Results: One from each intervention groups were lost to follow up. Both combined calcium- magnesium and calcium alone groups had better outcomes than the placebo group in pain intensity (adjusted difference -1.9, 95% confidence interval -2.2 to -1.7 and -0.9, -1.2 to -0.6, respectively), rest length (-2.5 hours, -3.2 to -1.9 and -1.7, -2.4 to -1.1) and number of Ibuprofen taken (-2.6, -4.1 to -1.1 and -1.5, -2.9 to -0.1). The calcium- magnesium group had significantly better outcomes than the calcium group in pain relief and rest length but not in the Ibuprofen taken. No side event was reported.
Conclusion: Both combined calcium-magnesium and calcium alone are effective in relieving the pain and decreasing rest length due to primary dysmenorrhea, but better efficacy was obtained from combined calcium and magnesium in comparison with its counterpart.
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