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Oct 2016, Vol 4, Issue 4
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Original Article
Effect of Intrauterine Injection of Human Chorionic Gonadotropin Before Frozen-Thawed Embryo Transfer on Implantation and Clinical Pregnancy Rate: A Randomized Controlled Trial
Robab Seyed Hosseini, Laya Farzadi, Sedigheh Abdollahi, Mohammad Nouri, Alieh Ghasemzadeh, Kobra Hamdi, Hassan Soleimanpour
Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

IJWHR 2016; 4: 189-193
DOI: 10.15296/ijwhr.2016.42
Viewed : 1151 times
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Keywords : Embryo transfer, Human chorionic gonadotropin, Implantation, Pregnancy
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Abstract
Objectives: This study aimed to assess the effect of intrauterine injection of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer on implantation and clinical pregnancy rates.

Materials and Methods: In this prospective randomized clinical trial, 100 infertile women younger than 40 years old were randomly divided into intervention (n = 50) and control groups (n = 50). Intervention group received intrauterine injection of 500 IU hCG before frozen-thawed embryo transfer, while control group had the embryo transferred without intrauterine hCG injection. Then, both groups were assessed in terms of implantation, clinical pregnancy and ongoing pregnancy rates. P <0.05 was considered statistically significant.

Results: There was a significant difference in clinical pregnancy rate between intervention (28%) and control (10.4%) groups (P = 0.028, OR: 4.28, CI: 1.25-14.14). The difference in ongoing pregnancy rate between intervention (28%) and control (8.3%) groups was also statistically significant (P = 0.012, OR: 3.44, CI: 1.1-1.18).

Conclusion: Intrauterine injection of hCG (500 IU) before frozen-thawed embryo transfer can significantly improve clinical and ongoing pregnancy in patients with history of in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).

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Articles by Seyed Hosseini R
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Articles by Hamdi K
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Articles by Laya Farzadi
Articles by Sedigheh Abdollahi
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Articles by Alieh Ghasemzadeh
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