|Effect of Intrauterine Injection of Human Chorionic Gonadotropin Before Frozen-Thawed Embryo Transfer on Implantation and Clinical Pregnancy Rate: A Randomized Controlled Trial|
|Robab Seyed Hosseini, Laya Farzadi, Sedigheh Abdollahi, Mohammad Nouri, Alieh Ghasemzadeh, Kobra Hamdi, Hassan Soleimanpour|
|Women?s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|
IJWHR 2016; 4: 189-193
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Keywords : Embryo transfer, Human chorionic gonadotropin, Implantation, Pregnancy
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Objectives: This study aimed to assess the effect of intrauterine injection of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer on implantation and clinical pregnancy rates.
Materials and Methods: In this prospective randomized clinical trial, 100 infertile women younger than 40 years old were randomly divided into intervention (n = 50) and control groups (n = 50). Intervention group received intrauterine injection of 500 IU hCG before frozen-thawed embryo transfer, while control group had the embryo transferred without intrauterine hCG injection. Then, both groups were assessed in terms of implantation, clinical pregnancy and ongoing pregnancy rates. P <0.05 was considered statistically significant.
Results: There was a significant difference in clinical pregnancy rate between intervention (28%) and control (10.4%) groups (P = 0.028, OR: 4.28, CI: 1.25-14.14). The difference in ongoing pregnancy rate between intervention (28%) and control (8.3%) groups was also statistically significant (P = 0.012, OR: 3.44, CI: 1.1-1.18).
Conclusion: Intrauterine injection of hCG (500 IU) before frozen-thawed embryo transfer can significantly improve clinical and ongoing pregnancy in patients with history of in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).
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