Hypersexuality refers to a clinical diagnosis used by mental health providers and researchers to describe a suddenly increased or extremely frequent sexual activity or sexual urges. The literature defines hypersexuality as a condition where affected persons exhibit excessive or unusual indulgence or concern with sexual activity. Sexologists have reported that hypersexuality can be a primary condition, or a symptom of the underlying medical sexual condition, such as a bipolar disorder, Parkinson disease, damaged kidney or impaired adrenal functions. The objective of the current review is to explore the hypersexual behavior in females and examine the role of sexual hormone secretion in proliferating the condition. Specific focus is to discuss how a hormonal imbalance in females could lead to hypersexuality if major glands in the body become impaired, including the adrenal cortex, the thyroid glands, pancreatic glands, and how medical conditions like cancer in these organs can also trigger hypersexual behavior. The study will also seek to verify if there is a link between medical conditions on the above organs and the normal secretion of sex hormones, which when triggered can cause an imbalance in hormone secretion resulting in excessive sexual urge and fantasies.