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Mar 2013, Vol 1, Issue 2
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Original Article
Evaluation of Testosterone and Alkaline Phosphatase Activity Changes in Epidydimis of Toxoplasma gondii Infected Rats
Fatemeh Afshari1, Amir Mahdi Imani2, Sasan Najjari Asl3, Hossein H.Farhang3, Khazar Ghasempour4, Amir Ezzatzadeh3, Nava Ainechi1
1Department of Histopathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3Department of Veterinary Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
4Medicine Student , Tabriz University of Medical Sciences , Tabriz , Iran

IJWHR 2013; 1: 064-071
DOI: 10.15296/ijwhr.2013.11
Viewed : 1889 times
Downloaded : 3130 times.

Keywords : Alkaline Phosphatase, Epididymis, Malondialdehyde, Testosterone, Toxoplasma gondii
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Abstract
Objective: Toxoplasma gondii is a widespread protozoan parasite that infects a broad range of warm blooded animals and humans. The present study was investigated to evaluate testosterone, alkaline phosphatase activity and malondialdehyde in male rats experimentally infected by Toxoplasma gondii, RH strain.

Material & Methods: Male Wistar rats (n=20) were allocated into two groups, group one (n=10) that received 0.6 cc tachyzoites of T. gondii intraperitoneally (I.P.), and control group (n=10) that received nothing. Animals were kept in standard conditions. 30 days after inducing Toxoplasma infection, 5cc blood was collected for assessment of serum testosterone, alkaline phosphatase and malondialdehyde levels. Epididymis tissues of Rats in whole groups were removed and prepared for analysis.

Results: Alkaline phosphatase, and Testosterone were significantly increased in group that was infected by T.gondii in comparison to control group (P<0.05). There was no significant difference in mean concentration of Malondialdehyde level in infected group in comparison to control group (p>0.05).

Epididymis weights in toxoplasmosis group was significantly decreased in comparison to control group (P<0.05). Positive brown alkaline phosphatase were observed in epididym tissue of infected toxoplasma group in comparison to control group.

Conclusion: This study showed that T. gondii has augmenter effects on alkaline phosphatase activity, testosterone and has harmful effect on epididymis tissue.

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Articles by Afshari F
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Articles by Fatemeh Afshari
Articles by Amir Mahdi Imani
Articles by Sasan Najjari Asl
Articles by Hossein H.Farhang
Articles by Khazar Ghasempour
Articles by Amir Ezzatzadeh
Articles by Nava Ainechi

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